Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents

J Med Chem. 1978 Nov;21(11):1137-40. doi: 10.1021/jm00209a009.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenine Nucleotides / chemical synthesis*
  • Adenine Nucleotides / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Fetus / enzymology*
  • In Vitro Techniques
  • Isoelectric Focusing
  • Isoenzymes / antagonists & inhibitors*
  • Kidney / enzymology
  • Kinetics
  • Liver / enzymology
  • Male
  • Muscles / enzymology
  • Neoplasms / enzymology*
  • Pyruvate Kinase / antagonists & inhibitors*
  • Rats
  • Structure-Activity Relationship

Substances

  • Adenine Nucleotides
  • Antineoplastic Agents
  • Isoenzymes
  • Pyruvate Kinase